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     Language Tips > 2003
    Updated: 2003-09-29 01:00

    Man's best friend, genetically more like him than a mouse
    狗——人類(lèi)最親密的朋友

    Dogs are genetically closer to man than mice, US researchers said, detailing a partial sequencing of the dog genome.

    The researchers at the Institute for Genomic Research and the Center for the Advancement of Genomics assembled 6.22 million sequences of dog DNA for nearly 80 percent coverage of the genome, they said in a statement.

    "Comparing the dog sequence data with current drafts of the human and mouse genome sequences showed that the dog lineage was the first to diverge from the common ancestor of the three species, and that the human and dog are much more similar to each other at the genetic level than to the mouse," they said in results published in the review Science.

    The project found that more than 25 percent, or 650 million base pairs, of DNA overlap between human and dog.

    "The sequence data was used to identify an equivalent dog gene for 75 percent of known human genes," they added.

    "In little more than a decade, genomics has advanced greatly and we now have approximately 150 completed genomes including the human, mouse and fruit fly, in the public domain," said Craig Venter, president of the TCAG.

    "Our new method is an efficient and effective way of sequencing that will allow more organisms to be analyzed while still providing significant information."

    (Agencies)

    美國(guó)研究者稱(chēng),他們仔細(xì)研究了狗的基因組部分序列,認(rèn)為從遺傳角度講狗比老鼠更接近人類(lèi)。

    基因組研究所和先進(jìn)基因體學(xué)研究中心的研究者們?cè)趫?bào)告中說(shuō)他們搜集了622萬(wàn)組狗的DNA序列,囊括了接近80%的基因組。

    他們?cè)凇犊茖W(xué)》雜志上發(fā)表的結(jié)果中提到:“通過(guò)比較狗基因組序列數(shù)據(jù)和現(xiàn)有的人類(lèi)基因組草圖以及老鼠的基因組序列,結(jié)果顯示狗類(lèi)家族首先從三者共同的祖先中分離出來(lái),在遺傳等級(jí)上狗比老鼠更接近人類(lèi),與人類(lèi)更相似。”

    該研究發(fā)現(xiàn)人類(lèi)和狗互相重合的DNA超過(guò)25%,相當(dāng)于6.5億鹼基對(duì)。

    他們還說(shuō):“序列數(shù)據(jù)被用來(lái)確認(rèn)與75%的已知人類(lèi)基因相對(duì)應(yīng)的狗的基因。”

    先進(jìn)基因體學(xué)研究中心主任克雷格·文特爾說(shuō)“在近十年里,基因體學(xué)發(fā)展迅速,我們?cè)陂_(kāi)放的領(lǐng)域里已經(jīng)有大約150組完整的基因組,包括人類(lèi),老鼠和果蠅。”

    “我們的新排序方法既經(jīng)濟(jì)又有效,能夠分析更多的生物體,提供重要的信息。”

    (中國(guó)日?qǐng)?bào)網(wǎng)站譯)

     
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