Global EditionASIA 中文雙語Fran?ais
    China
    Home / China / Innovation

    Chinese scientists achieve breakthrough in human DNA assembly, cross-species transfer

    Xinhua | Updated: 2025-07-16 16:05
    Share
    Share - WeChat

    TIANJIN -- A Chinese research team has made a significant leap in the field of synthetic biology by precisely synthesizing and assembling large-scale human DNA and successfully transferring it across species.

    This achievement not only advances the technology of human genome synthesis but also opens new avenues for treating genetic disorders, according to the researchers.

    The study, conducted by the state key laboratory of synthetic biology at Tianjin University, was recently published in the international journal Nature Methods under the title "De novo Assembly and Delivery of Synthetic Megabase-Scale Human DNA into Mouse Early Embryos."

    The team, led by Yuan Yingjin, an academician with the Chinese Academy of Sciences, developed a method called SynNICE. This method involves assembling synthetic human genomic DNA in yeast and then extracting the yeast nuclei with intact chromosomes using a technique called NICE (Nucleus Isolation for Chromosomes Extraction). The extracted nuclei, carrying the synthetic DNA, were then injected into the early embryos of mice.

    The researchers focused on a specific region of the human genome known as AZFa, located on the Y chromosome. This region is crucial for male fertility, and its deletion can lead to severe infertility with no current clinical solution. The AZFa region contains a high percentage of repetitive sequences, making it particularly challenging to synthesize and assemble. Despite this, the team successfully synthesized this region in yeast and transferred it to mouse embryos.

    For the first time, the team observed the transcription of the synthetic human DNA in mouse embryos. This study not only shows how cellular environments can reshape synthetic genomes but also holds promise for future biomedical applications.

    Top
    BACK TO THE TOP
    English
    Copyright 1995 - . All rights reserved. The content (including but not limited to text, photo, multimedia information, etc) published in this site belongs to China Daily Information Co (CDIC). Without written authorization from CDIC, such content shall not be republished or used in any form. Note: Browsers with 1024*768 or higher resolution are suggested for this site.
    License for publishing multimedia online 0108263

    Registration Number: 130349
    FOLLOW US
     
    久久无码精品一区二区三区| 中文无码喷潮在线播放| 寂寞少妇做spa按摩无码| 亚洲精品人成无码中文毛片| 亚洲性无码一区二区三区| 亚洲欧美日韩中文字幕在线不卡| 久久精品无码一区二区三区免费 | 亚洲AV无码国产精品色午友在线| 日韩欧美一区二区不卡中文| 久久精品无码一区二区app| 无码人妻一区二区三区兔费 | 无码国产69精品久久久久网站| 最近中文字幕电影大全免费版| 一级毛片中出无码| 国产成人无码精品久久久久免费| 亚洲大尺度无码无码专区| 中文无码不卡的岛国片| 欧美中文字幕在线视频| 中文字幕av无码一区二区三区电影| 免费无码国产V片在线观看| 人妻少妇精品无码专区二区| 亚洲AV无码乱码在线观看富二代| AV色欲无码人妻中文字幕| 一本一道色欲综合网中文字幕| 中文字幕视频一区| 中文字幕久久欲求不满| 最好看的中文字幕2019免费| 亚洲欧美日韩中文字幕在线不卡| 91视频中文字幕| 亚洲综合日韩中文字幕v在线| 人妻中文字系列无码专区| 无码精品日韩中文字幕| 亚洲国产a∨无码中文777| 天堂а√在线中文在线最新版| 亚洲人成中文字幕在线观看| 亚洲va中文字幕无码久久不卡| 香蕉伊蕉伊中文视频在线| 最近2019年中文字幕6| 亚洲日韩中文在线精品第一| 少妇无码AV无码一区| 亚洲av永久无码精品秋霞电影影院 |